• Rong-Luh Lin, Fung-J Lin, Chien-Liang Wu, Ming-Jen Peng, Pei-Jan Chen, and Hsu-Tah Kuo.
• Pulmonary Division, Department of Internal Medicine, Mackay Memorial Hospital, Taipei, Taiwan. rongluh@seed.net.tw
• J Formos Med Assoc. 2006 Aug 1; 105 (8): 636-44.

Background/PurposeTuberculosis (TB) continues to pose a heavy public health burden in Taiwan. This prospective study analyzed the factors influencing treatment outcome in patients with TB treated with and without a hospital-based case management (HBCM) approach in a referral center in Taipei.MethodsA register-based cohort study design was used to enroll all new cases of pulmonary or extrapulmonary TB from February 2003 to January 2004. The case manager served as the coordinator among patients, physicians and public health nurses, to facilitate compliance with anti-TB treatment. Treatment outcomes were assessed according to the consensus recommendations of the World Health Organization and the International Union Against Tuberculosis and Lung Disease.ResultsSuspected or confirmed pulmonary or extrapulmonary TB was diagnosed in 524 patients in our hospital from February 2003 to January 2004. Fifty-two of these patients were excluded due to duplicate reporting, previous treatment or death before enrollment. Out of 472 patients enrolled, 103 whose original diagnosis was revised were further excluded, leaving 369 cases eligible for analysis. Patients with case management had a significantly higher rate of successful treatment (cured plus completed treatment) compared to patients without case management, (240/277, 86.6% vs. 67/92, 72.8%; p = 0.002). The overall successful treatment rate including both case and non-case management was 83.2% (307/369), which was higher than the nationwide surveillance data of 78.3% in 2002 and 69.4% in 2003.ConclusionTreatment of TB patients by a HBCM approach provides improved treatment outcomes compared to those without case management.

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