• Izaskun Azkarate, Mikel Díez, Maialen Ganzarain, Estibaliz Salas, Gabriel Choperena, and Itziar Eguibar.
• Servicio de Medicina Intensiva, Hospital Universitario Donostia, San Sebastián, Guipúzcoa, España. Electronic address: izasazkarate@gmail.com.
• Med Clin (Barc). 2021 Jan 8; 156 (1): 13-16.

BackgroundIn addition to being effective at lowering cholesterol, statins seem to have immunomodulatory, antimicrobial, antioxidant and anticoagulant effects.ObjectiveTo determine whether the presentation of sepsis and its outcome in patients who have had prehospital statin therapy are different.MethodsA prospective, observational study was carried out on 1042 septic patients, for 5 consecutive years in the Intensive Care Unit (ICU) of a tertiary hospital.Results317 (30.4%) septic patients were receiving statins prior to hospitalization. Patients on statin therapy were older (69.7 years old vs 62.5; p <.001), males (71.9% vs 65.7%; p=.047) and with a higher mean Acute Physiology and Chronic Health Evaluation (APACHE) II score (21.7 vs 20.1; p<.001). Renal dysfunction was observed in a greater proportion (60.3% vs 51.5%; p=.009) in statin users but without requiring more continuous renal replacement therapies (CRRT). No differences were observed in Sequential Organ Failure Assessment (SOFA) score, procalcitonin levels, source of infection, microorganism and nosocomial infections in ICU and hospital mortality or length of stay.ConclusionsStatin therapy prior to hospitalization does not significantly influence sepsis presentation or sepsis outcomes.Copyright © 2020 Elsevier España, S.L.U. All rights reserved.

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