• Alessandro Picelli, Paola Bonetti, Carla Fontana, Martina Barausse, Francesca Dambruoso, Francesca Gajofatto, Paolo Girardi, Mario Manca, Raffaele Gimigliano, and Nicola Smania.
• Neuromotor and Cognitive Rehabilitation Research Center, Department of Neurological, Neuropsychological, Morphological and Movement Sciences, University of Verona, Verona, Italy.
• Arch Phys Med Rehabil. 2012 Jul 1; 93 (7): 1253-8.

ObjectiveTo investigate the relationship between gastrocnemius muscle echo intensity and response to botulinum toxin type A (BoNT-A) in patients with spastic equinus foot resulting from stroke.DesignCohort study.SettingUniversity hospital.ParticipantsAdult patients (N=56) with spastic equinus foot resulting from stroke scheduled to receive BoNT-A injection into the gastrocnemius muscle.InterventionsAll patients were injected with BoNT-A (abobotulinumtoxinA) into the gastrocnemius muscle with an ultrasonography-guided, multisite injection technique. The toxin dose was 250U for the gastrocnemius medialis and 250U for the gastrocnemius lateralis (dilution 500U/2mL) in each patient. All patients were evaluated before and 4 weeks after BoNT-A injection.Main Outcome MeasuresSpastic gastrocnemius muscle echo intensity visually graded with the Heckmatt scale. Clinical assessment of the spastic gastrocnemius with the Modified Ashworth Scale, Tardieu Scale, and ankle passive range of motion.ResultsPostintervention testing at 4 weeks showed overall significant improvements in the clinical assessment of the spastic gastrocnemius muscle. No significant change was observed in the echo muscle intensity of the spastic gastrocnemius after BoNT-A injection. Post hoc comparisons showed that all clinical outcomes were significantly better in those patients with echo muscle intensity of the spastic gastrocnemius graded II on the Heckmatt scale than those with grades III (P<.001) and IV (P<.001) after botulinum toxin injection.ConclusionsThese findings support the hypothesis that patients with higher spastic muscle echo intensity have a reduced response to BoNT-A.Copyright © 2012 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.

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