• Anesthesiology clinics · Dec 2010

    Review

    Molecular approaches to improving general anesthetics.

    • Stuart A Forman.
    • Department of Anesthesia, Critical Care & Pain Medicine, Massachusetts General Hospital, Jackson 4, MGH, 55 Fruit Street, Boston, MA 02114, USA. saforman@partners.org
    • Anesthesiol Clin. 2010 Dec 1; 28 (4): 761-71.

    AbstractOver the last several decades, the average age of patients has steadily increased, whereas the use of general anesthesia and deep sedation has grown largely outside the operating room environment. Currently available general anesthetics and delivery models represent limitations in addressing these trends. At the same time, research has tremendously expanded the knowledge of how general anesthetics produce their beneficial effects and also revealed evidence of previously unappreciated general anesthetic toxicities. The goal of this review is to highlight these important developments and describe translational research on new general anesthetics with the potential to improve and reshape clinical care.Copyright © 2010 Elsevier Inc. All rights reserved.

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