-
Review
Drug dosing in the critically ill obese patient-a focus on sedation, analgesia, and delirium.
- Brian L Erstad and Jeffrey F Barletta.
- Department of Pharmacy Practice & Science, University of Arizona, College of Pharmacy, 1295 N Martin Ave, PO Box 210202, Tucson, AZ, 85721, USA.
- Crit Care. 2020 Jun 8; 24 (1): 315.
AbstractPractice guidelines provide clear evidence-based recommendations for the use of drug therapy to manage pain, agitation, and delirium associated with critical illness. Dosing recommendations however are often based on strategies used in patients with normal body habitus. Recommendations specific to critically ill patients with extreme obesity are lacking. Nonetheless, clinicians must craft dosing regimens for this population. This paper is intended to help clinicians design initial dosing regimens for medications commonly used in the management of pain, agitation, and delirium in critically ill patients with extreme obesity. A detailed literature search was conducted with an emphasis on obesity, pharmacokinetics, and dosing. Relevant manuscripts were reviewed and strategies for dosing are provided.
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