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Dtsch. Med. Wochenschr. · Jun 2020
[Current Recommendations for the First-Line Therapy of Symptomatic Multiple Myeloma].
- Lukas John, Hartmut Goldschmidt, and Christof Scheid.
- Dtsch. Med. Wochenschr. 2020 Jun 1; 145 (12): 813-819.
AbstractDue to the introduction of novel therapeutic agents, the prognosis of Multiple Myeloma has greatly improved over the last decades. The current standard for fit patients is a bortezomib-based induction therapy, followed by high-dose chemotherapy and autologous stem cell transplantation and lenalidomide-based maintenance therapy. For older, non-transplant-eligible patients, daratumumab in combination with bortezomib or lenalidomide offers a well-tolerated, effective treatment option. Despite large improvements, there is still no cure for most myeloma patients, the aim of therapy is therefore to reach a deep remission to prevent lasting damage followed by a continuous maintenance therapy to uphold the remission and prolong overall survival.© Georg Thieme Verlag KG Stuttgart · New York.
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