• World Neurosurg · Sep 2020

    Posterior cranial fossa maldevelopment in infants with repaired open myelomeningoceles. Double trouble or a dynamic process of posterior cranial fossa abnormalities?

    • Rosalinda Calandrelli, Fabio Pilato, Luca Massimi, Marco Panfili, Concezio Di Rocco, and Cesare Colosimo.
    • Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Radiology and Neuroradiology, Diagnostics For Images, Radiotherapy, Oncology and Hematology, Diagnostic Area for Images, Rome, Italy.
    • World Neurosurg. 2020 Sep 1; 141: e989-e997.

    ObjectiveTwo degrees of posterior cranial fossa (PCF) maldevelopment can be hypothesized in children with myelomeningocele (MMC). This paper investigates the PCF deformation by quantitative magnetic resonance imaging analysis in MMC subjects with and without Chiari 2 malformation (CM2).MethodsPCF bone volume (PCFV), PCF brain volume (PCFBV), lengths of PCF, ventriculomegaly, level, and extension of the dysraphism were analyzed by magnetic resonance image scanning of 51 newborns with MMC surgically repaired at birth (and 41 controls). The possible correlation among PCF hypoplasia, level/extension of the spinal dysraphism, and ventriculomegaly was assessed.ResultsIn MMC and CM2, the dysraphism level was above L4 in 30 and below L4 in 10 subjects. PCFV/PCFBV ratio and supraocciput and exocciput lengths were significantly reduced; foramen magnum diameters, mammillo-pontine distance, and pons length were significantly increased (P < 0.05). In isolated MMC, the dysraphism level was below L4 in all cases. PCFV/PCFBV ratio and supraocciput length were significantly reduced; pons length was significantly increased (P < 0.05). The lower the MMC level, the lower the incidence of CM2. A positive correlation was found between PCF hypoplasia and MMC level above L4 (P < 0.001), while a negative correlation was found among PCF hypoplasia and MMC extension (P = 0.006), PCF hypoplasia, and ventriculomegaly (P = 0.02).ConclusionsPCF hypoplasia has to be considered a dynamic maldevelopment process in the 2 cohorts rather than 2 separated entities. The level of MMC is the main but not the unique cause influencing the severity of PCF maldevelopment.Copyright © 2020 Elsevier Inc. All rights reserved.

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