• Baeki E Kang, Jun-Yong Choi, Sokrates Stein, and Dongryeol Ryu.
• Molecular and Integrative Biology Lab (MIB), Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon, Korea.
• Eur. J. Clin. Invest. 2020 Oct 1; 50 (10): e13334.

AbstractNicotinamide adenine dinucleotide (NAD+ ) is an essential metabolite in energy metabolism as well as a co-substrate in biochemical reactions such as protein deacylation, protein ADP-ribosylation and cyclic ADP-ribose synthesis mediated by sirtuins, poly (ADP-ribose) polymerases (PARPs) and CD38. In eukaryotic cells, NAD+ is synthesized through three distinct pathways, which offer different strategies to modulate the bioavailability of NAD+ . The therapeutic potential of dietarily available NAD+ boosters preserving the NAD+ pool has been attracting attention after the discovery of declining NAD+ levels in ageing model organisms as well as in several age-related diseases, including cardiometabolic and neurodegenerative diseases. Here, we review the recent advances in the biology of NAD+ , including the salubrious effects of NAD+ boosters and discuss their future translational strategies.© 2020 Stichting European Society for Clinical Investigation Journal Foundation.

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