• Wen-Wen Cheng, Ze-Kun Wang, Huang-Fang Shangguan, Qiang Zhu, and Hong-Yu Zhang.
• Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University, Wuhan, People's Republic of China.
• Nutrition. 2020 Oct 1; 78: 110870.

ObjectiveThe relationship between vitamin intake and the occurrence of cancer is controversial. The aim of this study was to examine the genetic associations between vitamins D, E, and B12 and five cancers (i.e., colorectal cancer, breast cancer, prostate cancer, malignant melanoma, and squamous cell carcinoma).MethodsThis study started from genome-wide association data for three vitamins (N = 11 238) and five cancers (N = 373 316). The study analyzed their associations using Mendelian randomization (MR) methods. Additionally, survival analysis was performed using data from The Cancer Genome Atlas (TCGA) to further evaluate some MR results.ResultsMR analysis indicated that intake of vitamins D, E, and B12 is not relevant to the risk for the five cancers (PMR > Bonferroni-corrected P = 0.02). Some of the results were supported by epidemiological observations; some were further supported by survival analysis using TCGA data.ConclusionThere is no genetic evidence to support the association between intake of vitamins D, E, and B12 and the risk for colorectal, breast, and prostate cancers, malignant melanoma, and squamous cell carcinoma.Copyright © 2020 Elsevier Inc. All rights reserved.

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