• British medical bulletin · Mar 2016

    Review

    Human uterus transplantation in focus.

    • Pernilla Dahm-Kähler, Cesar Diaz-Garcia, and Mats Brännström.
    • Department of Obstetrics and Gynecology, Sahlgrenska Academy, University of Gothenburg, 41345 Gothenburg, Sweden.
    • Br. Med. Bull. 2016 Mar 1; 117 (1): 69-78.

    IntroductionUterus transplantation (UTx) is introduced as the first treatment for absolute uterine factor infertility (AUFI), affecting 1:500 fertile aged women. This review presents potential patients, research and human UTx cases.Sources Of DataPublished articles and our research experience.Areas Of AgreementThe first UTx live births in 2014 established UTx as a possible treatment for AUFI. This was proceeded by 15 years of systematic research.Areas Of ControversyIs a deceased donor UTx as effective as the proven successful live donor UTx?.Growing PointsHuman UTx trials will accumulate data on risks, effectiveness and long-term consequences for donors, recipients and children. These should also include aspects of quality of life, psychological well-being and cognitive/neuropsychiatric development of children.Areas Timely For Developing ResearchAll new activities in human UTx within the coming years should be conducted as prospective observational studies, and data should also be collected within an international registry.© The Author 2016. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

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