• Sara Goldhaber-Fiebert and Loreta Grecu.
• Department of Anesthesia and Critical Care, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
• Ann. Allergy Asthma Immunol. 2006 Oct 1; 97 (4): 449-53.

BackgroundAnaphylaxis must be recognized and treated promptly to avoid significant morbidity and mortality. In this clinical setting, electrocardiographic changes can be multifactorial.ObjectiveTo discuss vasospasm as a cause of myocardial ischemia and its possible triggering by anaphylaxis itself or by the administration of epinephrine.MethodsWe describe a patient with multiple previous allergies who received intravenous epinephrine to treat suspected anaphylaxis. She immediately developed crushing chest pain with ST-segment elevations in the inferior leads. Throughout the discussion, we address differential diagnoses, physiologic features, and treatment.ResultsHer symptoms and electrocardiographic changes were consistent with vasospasm, which resolved after treatment with sublingual nitroglycerin. However, the reaction was sufficient to cause an elevation in the troponin T level and, therefore, myocardial damage on the cellular level.ConclusionsCardiovascular complications, including electrocardiographic changes, may be induced by anaphylactic mediators or by medications used for its treatment.

22 keywords...

hide…