• British medical bulletin · Jun 2019

    Review

    Neuroinflammation is a putative target for the prevention and treatment of perioperative neurocognitive disorders.

    • S Saxena, I K Lai, R Li, and M Maze.
    • Department of Anesthesia, CHU-Charleroi, Université Libre de Bruxelles, Charleroi, Belgium.
    • Br. Med. Bull. 2019 Jun 19; 130 (1): 125-135.

    IntroductionThe demographics of aging of the surgical population has increased the risk for perioperative neurocognitive disorders in which trauma-induced neuroinflammation plays a pivotal role.Sources Of DataAfter determining the scope of the review, the authors used PubMed with select phrases encompassing the words in the scope. Both preclinical and clinical reports were considered.Areas Of AgreementNeuroinflammation is a sine qua non for development of perioperative neurocognitive disorders.Areas Of ControversyWhat is the best method for ameliorating trauma-induced neuroinflammation while preserving inflammation-based wound healing.Growing PointsThis review considers how to prepare for and manage the vulnerable elderly surgical patient through the entire spectrum, from preoperative assessment to postoperative period.Areas Timely For Developing ResearchWhat are the most effective and safest interventions for preventing and/or reversing Perioperative Neurocognitive Disorders.© The Author(s) 2019. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

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