• World Neurosurg · Dec 2020

    Comparative analysis of NF KB in the MyD88 mediated pathway after implantation of titanium alloy and stainless steel and the role of regulatory T cells.

    • Sibel Akyol, Mehmet Yigit Akgun, Mehmet Yetmez, Murat Hanci, Faik Nuzhet Oktar, and Besim Ben-Nissan.
    • Department of Physiology, Istanbul University-Cerrahpasa, Istanbul, Turkey; Faculty of Science, School of Life Sciences, University of Technology Sydney, Sydney, Australia.
    • World Neurosurg. 2020 Dec 1; 144: e138-e148.

    ObjectiveDevelopment of immunologically smart implants, integrated to biological systems, is a key aim to minimize the inflammatory response of the host to biomaterial implants.MethodsThe aim of this study is to investigate the influence of titanium alloy and stainless steel implants on immunological responses in rats by comparative analysis of nuclear factor kappa B (NF-κB) profiles in the activation of inflammatory signaling pathways and the role of CD4+CD25+Foxp3+.ResultsBoth Ti alloy and stainless steel alloy group implantation affect Toll-like receptors-4 pathways and CD4+CD25+ regulatory T cells in different ways.ConclusionsResults show that NF-κB/p65 and NF-κB1/p50 possess potential as a therapeutic target in the prevention of adverse reactions to metal, especially for controlling inflammation after the implantation.Copyright © 2020 Elsevier Inc. All rights reserved.

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