• Zheng Li, Qian Zhang, Peng Zhang, Ruixiang Sun, Haijiao Jiang, JingJing Wan, Fang Wu, Xiaoye Wang, and Xiubin Tao.
• Graduate College, Wannan Medical College, Wuhu.
• Medicine (Baltimore). 2020 Sep 4; 99 (36): e22013.

BackgroundIntensive care unit-acquired weakness (ICU-AW) is an acquired neuromuscular lesion and a common occurrence in patients who are critically ill. We will systematically summarize and incorporate the important risk factors and prevalence from previously published multivariate analyses for ICU-AW.MethodsWe will search the PubMed, Embase, Web of Science, and the Cochrane library to identify the relevant studies about the prevalence and risk factors for ICU-AW. Two reviewers will independently review the studies for eligibility according to the inclusion criteria. Two reviewers will independently assess the quality of studies by using the Newcastle-Ottawa scale for nonrandomized studies. Heterogeneity among studies will be estimated by the I statistic.ResultsThis systematic review and meta-analysis will provide an evidence of prevalence and risk factors for the ICU-AW.ConclusionWe hope that our research will contribute to clinicians and public decision making about the ICU-AW.

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