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- Cameron Dezfulian and Eric J Lavonas.
- Critical Care Medicine, University of Pittsburgh School of Medicine, 4401 Penn Avenue, CHP Faculty Pavilion, Room 2119, Pittsburgh, PA 15224, USA; Clinical and Translational Sciences, University of Pittsburgh School of Medicine, 4401 Penn Avenue, CHP Faculty Pavilion, Room 2119, Pittsburgh, PA 15224, USA. Electronic address: dezfulianc@upmc.edu.
- Crit Care Clin. 2020 Oct 1; 36 (4): 737-752.
AbstractCardiac arrest results from a broad range of etiologies that can be broadly grouped as sudden and asphyxial. Animal studies point to differences in injury pathways invoked in the heart and brain that drive injury and outcome after these different forms of cardiac arrest. Present guidelines largely ignore etiology in their management recommendations. Existing clinical data reveal significant heterogeneity in the utility of presently employed resuscitation and postresuscitation strategies based on etiology. The development of future neuroprotective and cardioprotective therapies should also take etiology into consideration to optimize the chances for successful translation.Copyright © 2020 Elsevier Inc. All rights reserved.
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