• Saba Tariq, Sundus Tariq, Shaista Hussain, and Mukhtiar Baig.
• Saba Tariq, MBBS, M.Phil. Associate Professor of Pharmacology, University Medical & Dental College, University of Faisalabad, Pakistan, Research Scholar, Pharmacology, University of Health Sciences, Lahore, Pakistan.
• Pak J Med Sci. 2020 Sep 1; 36 (6): 1325-1329.

ObjectiveTo determine the association of serum osteoprotegerin (OPG) with the severity of chronic liver disease in female patients.MethodsThis case-control study was conducted in Madina Teaching Hospital from 2019-2020.An institutional review board of University Medical and Dental College, The University of Faisalabad gave the approval to conduct the study. Only female patients of age group 40 to 60 years having CLD were included in this study. Total 80 participants were enrolled after fulfilling the inclusion and exclusion criteria. Serum OPG levels were measured by enzyme linked immunosorbant assay (ELISA) supplied by ELAB Sciences, USA. The severity of disease was assessed by Child-Pugh classification.ResultsOPG levels were significantly different between the three Child-Pugh classes. OPG levels were significantly high in class C indicating increased level of this cytokine in CLD as compared to class A (p = <0.05). There was a positive association of OPG with splenomegaly (OR = 2.10, p = <0.001), hepatomegaly (OR = 4.41, (p = <0.05), skin pigmentation (OR = 2.06, p = <0.05), malena (OR = 1.87, p = <0.05) and prolonged bleeding (OR = 1.86, p = <0.05).ConclusionThe levels of serum Osteoprotegerin is increased in severe form of chronic liver disease (Class C) of Child-Pughs classification as compared to mild (Class A) and moderate (Class B) forms of Child-Pughs classification.Copyright: © Pakistan Journal of Medical Sciences.

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