• Samara R Medeiros, Natalia Pinheiro-Rosa, Luisa Lemos, Flavia G Loli, Alline G Pereira, Andrezza F Santiago, Ester C Pinter, Andrea C Alves, Jamil S Oliveira, Denise C Cara, Tatiani U Maioli, and Ana Maria C Faria.
• Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
• Nutrition. 2015 Oct 1; 31 (10): 1260-5.

AbstractDietary compounds, including micronutrients such as vitamin A and its metabolite retinoic acid, directly influence the development and function of the immune system. In this study, we show that either dietary deficiency of or supplementation with vitamin A had immunologic effects in mice that were fed these diets during their development (for 8 wk during the postweaning period). Deficient mice presented higher levels of interferon-γ, interleukin (IL)-6, transforming growth factor-β, IL-17, and IL-10 in the gut-associated lymphoid tissues and draining lymph nodes, indicating a proinflammatory shift in the gut mucosa. Serum immunoglobulin G levels also were elevated in these mice. Conversely, supplemented mice showed higher frequencies of CD4+Foxp3+LAP+ regulatory T cells in gut lymphoid tissues and spleen, suggesting that vitamin A supplementation in the diet may be beneficial in pathologic situations such as inflammatory bowel diseases.Copyright © 2015 Elsevier Inc. All rights reserved.

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