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- Andrew Faramand, Ajay Niranjan, John Flickinger, Edward Monaco, and L Dade Lunsford.
- Department of Neurological Surgery and Radiation Oncology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA. Electronic address: faramanda@upmc.edu.
- World Neurosurg. 2020 Dec 1; 144: 205-208.
BackgroundManagement of intracranial Langerhans cell histiocytosis generally includes surgical resection.Case DescriptionA female patient with a diagnosis of Langerhans cell histiocytosis developed multiple brain lesions. As part of her multimodality treatment, she underwent Gamma Knife stereotactic radiosurgery on 4 occasions over a 20-year period. All tumors showed significant shrinkage on serial imaging after initially demonstrating a transient expansion. No permanent postradiosurgery complications occurred.ConclusionsAs part of multimodality management of this recurrent and refractory disease, Gamma Knife stereotactic radiosurgery should be considered an important salvage option that can control local disease and obviate the need for invasive surgery.Copyright © 2020 Elsevier Inc. All rights reserved.
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