• Samuel Átila Rodrigues Nogueira, Samuel Ciríaco Silva de Oliveira, Ana Flávia Moreira de Carvalho, Julia Moreira Cavalcante Neves, Leila Silveira Vieira da Silva, Silva Junior Geraldo Bezerra da GBD http://orcid.org/0000-0002-8971-0994 . Universidade de Fortaleza, Curso de Medicina, Programas de Pós-Graduação em, and Maria Elizabeth Pereira Nobre.
• . Universidade Federal do Cariri, Faculdade de Medicina, Barbalha, CE, Brasil.
• Rev Assoc Med Bras (1992). 2020 Jan 1; 66Suppl 2 (Suppl 2): 112-117.

ObjectiveWe aimed to present a review of renal changes in patients with COVID-19.MethodsWe performed a systematic review of the literature to identify original articles regarding clinical, laboratory, and anatomopathological kidney changes in patients infected with SARS-CoV-2 published until May 7, 2020. The search was carried out across PubMed, Scopus, and Embase using the keywords "COVID-19", "coronavirus", "SARS-CoV-2", "kidney injury" and "kidney disease". Fifteen studies presented clinical and laboratory renal changes in patients with COVID-19, and three addressed anatomopathological changes.DiscussionAcute kidney injury (AKI) was a relevant finding in patients with COVID-19. There were also significant changes in laboratory tests that indicated kidney injury, such as increased serum creatinine and blood urea nitrogen (BUN), proteinuria, and hematuria. The presence of laboratory abnormalities and AKI were significant in severely ill patients. There was a considerable prevalence of AKI among groups of patients who died of COVID-19. Histopathological analysis of the kidney tissue of patients infected with SARS-CoV-2 suggested that the virus may directly affect the kidneys.ConclusionAlthough COVID-19 affects mainly the lungs, it can also impact the kidneys. Increased serum creatinine and BUN, hematuria, proteinuria, and AKI were frequent findings in patients with severe COVID-19 and were related to an increased mortality rate. Further studies focusing on renal changes and their implications for the clinical condition of patients infected with the novel coronavirus are needed.

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