• Yong Huan Cui, Yoon Ji Choi, Eung Hwi Kim, Joon Ho Yu, Hyun Young Seong, Sung-Uk Choi, Seung Zhoo Yoon, and Hyub Huh.
• Department of Medicine, Graduate School Korea University, Seoul, Republic of Korea.
• Medicine (Baltimore). 2020 Sep 25; 99 (39): e22218.

BackgroundChlorhexidine and silver sulfadiazine coated central venous catheters (CSS-CVC) may cause loss of antimicrobial efficacy due to friction between the CVC surface and sheer stress caused by the blood flow. Therefore, the aim of this study was to investigate the antibacterial efficacy of CSS-CVC at various flow rates using a bloodstream model.MethodsEach CVC was subjected to various flow rates (0.5, 1, 2, and 4 L/min) and wear-out times (0, 24, 48, 72, 96, and 120 hours), and the optical density (OD) 600 after a Staphylococcus aureus incubation test was used to determine the antibacterial effect of CSS-CVC.ResultsIn the 0.5 L/min group, there was no significant change in the OD600 value up to 120 hours compared with the baseline OD600 value for CSS-CVC (P > .467). However, the OD600 values of CSS-CVC in the 1 L/min (P < .001) and 2 L/min (P < .001) groups were significantly reduced up to 72 hours, while that in the 4 L/min (p < 0.001) group decreased rapidly up to 48 hours.ConclusionThis study suggests that there is a doubt whether sufficient antibacterial function can be maintained with prolonged duration of catheter placement.

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