• Salih Cagri Cakir, Bayram Ali Dorum, Nilgun Koksal, and Hilal Ozkan.
• Salih Cagri Cakir, Medical Doctor, Department of Pediatrics, Division of Neonatology, Uludag University Medical Faculty, Gorukle, 16059, Nilufer-Bursa-Turkey.
• Pak J Med Sci. 2020 Jan 1; 36 (2): 26-31.

ObjectiveTo investigate the effects of maternal preeclampsia on inflammatory cytokines and neonatal outcomes in premature infants.MethodsThe study included preterm infants born at gestational age ≤32 weeks in a tertiary university hospital between January 2016 and January 2017. The study group consisted of infants born from mothers with preeclampsia (Group-1), and the control group consisted of infants born from normotensive mothers (Group-2). Demographic characteristics and clinical outcomes of the infants were recorded. IL-6, IL-8, IL-10, and TNF-α cytokine levels were measured from umbilical cord blood samples.ResultsA total of 108 infants were included in the study, of which 34 were in the Group-1 and 74 in the Group-2. Gestational ages (29 vs 30 weeks) of the infants in both groups were similar. There was no significant difference between the cytokine levels of infants with and without preeclampsia. The rate of small for gestational age, retinopathy of prematurity, intraventricular hemorrhage, necrotizing enterocolitis, neutropenia, and thrombocytopenia were significantly higher at the infants with preeclampsia.ConclusionMaternal preeclampsia leads to an increase at the neonatal morbidities in premature infants without causing a significant alteration at the cytokine levels in cord blood.Copyright: © Pakistan Journal of Medical Sciences.

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