• Rev Assoc Med Bras (1992) · Sep 2020

    Review

    Pharmacological therapy and cardiovascular risk reduction for type 2 diabetes.

    • Eduardo Bello Martins, Eduardo Gomes Lima, Fábio Grunspun Pitta, Leticia Neves Solon Carvalho, Thiago Dias de Queiroz, and Carlos Vicente Serrano Júnior.
    • Departamento de Aterosclerose, Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina, USP (InCor-HCFMUSP).
    • Rev Assoc Med Bras (1992). 2020 Sep 1; 66 (9): 1283-1288.

    AbstractThe pharmacological therapy for type 2 diabetes mellitus has presented important advances in recent years, which has impacted the treatment of patients with established cardiovascular disease or with high cardiovascular risk. In this scenario, two drug classes have emerged and demonstrated clear clinical benefits: SGLT-2 inhibitors and GLP-1 agonists. The present review discusses the pharmacology, adverse effects, and clinical trials that have demonstrated the benefits of these medications in reducing cardiovascular risk.

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