Pharmacologic issues of antiretroviral agents and

Infect. Dis. Clin. North Am. · Jun 2013

Review

Pharmacologic issues of antiretroviral agents and immunosuppressive regimens in HIV-infected solid organ transplant recipients.

HIV-positive patients are now undergoing solid organ transplantation at increasing rates, with successful outcomes. Transplantation in this unique patient population presents new challenges in the postoperative management of both antiretroviral regimens and immunosuppressive regimens. This review highlights the drug-drug interactions between commonly used immunosuppressive and antiretroviral agents. As more antiretroviral regimens are cautiously initiated in the posttransplant period, further research is needed to identify drug-drug interactions to minimize toxicities and improve long-term survival and graft function.

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- Jennifer Primeggia, Joseph G Timpone, and Princy N Kumar.
- Georgetown University Medical Center, Division of Infectious Diseases, Department of Medicine, Washington, DC 20007-2113, USA. jxprime@gmail.com
- Infect. Dis. Clin. North Am. 2013 Jun 1; 27 (2): 473-86.
AbstractHIV-positive patients are now undergoing solid organ transplantation at increasing rates, with successful outcomes. Transplantation in this unique patient population presents new challenges in the postoperative management of both antiretroviral regimens and immunosuppressive regimens. This review highlights the drug-drug interactions between commonly used immunosuppressive and antiretroviral agents. As more antiretroviral regimens are cautiously initiated in the posttransplant period, further research is needed to identify drug-drug interactions to minimize toxicities and improve long-term survival and graft function.Copyright © 2013 Elsevier Inc. All rights reserved.

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Pharmacologic issues of antiretroviral agents and immunosuppressive regimens in HIV-infected solid organ transplant recipients.

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