• Qing Long, Liang Ao, Kuo Li, and Yan Li.
• Department of Traditional Chinese Medicine, The Affiliated Hospital of Southwest Medical University.
• Medicine (Baltimore). 2020 Oct 9; 99 (41): e22402.

BackgroundSulindac has been used for treating colorectal polyps widely. However, the efficacy and safety of sulindac for colorectal polyps are unclear. This study aims to evaluate the efficacy and safety of sulindac for colorectal polyps.MethodsRandomized controlled trials of sulindac in the treatment of colorectal polyps will be searched in PubMed, EMbase, Cochrane Library, Web of Science, China National Knowledge Infrastructure (CNKI), WanFang, the Chongqing VIP Chinese Science, and Technology Periodical Database, and China biomedical literature database (CBM) from inception to August, 2020. And Baidu Scholar, Google Scholar, International Clinical Trials Registry Platform, and Chinese Clinical Trials Registry will be searched to obtain more relevant studies comprehensively. Two researchers will perform data extraction and risk of bias assessment independently. Statistical analysis will be conducted in RevMan 5.3.ResultsThis study will summarize the present evidence by exploring the efficacy and safety of sulindac in the treatment of colorectal polyps.ConclusionThe findings of the study will provide helpful evidence for the efficacy and safety of sulindac in the treatment of colorectal polyps, facilitating clinical practice and further scientific studies.Ethics And DisseminationThe private information from individuals will not publish. This systematic review also will not involve endangering participant rights. Ethical approval is not required. The results may be published in a peer-reviewed journal or disseminated in relevant conferences.Osf Registration NumberDOI 10.17605/OSF.IO/N5GDH.

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