• Ruiqi Mao, Lifang Shi, Wei Yan, Wenli Li, Baicheng Li, and Xinjun Li.
• Department of Pathology, Binzhou People's Hospital of Shandong Province, Binzhou, China.
• Medicine (Baltimore). 2020 Oct 16; 99 (42): e22783.

RationaleAnaplastic thyroid carcinoma (ATC) is a rare highly aggressive thyroid malignancy. Thyroid sclerosing mucoepidermoid carcinoma with eosinophilia is also a rare low grade malignant thyroid neoplasm. To date, comorbidity of these 2 tumors in the thyroid gland has not been reported in the English literature.Patient ConcernsHere, we present a case of a 67-year-old women with a 6-month history of mass of left neck. She complained of a painless mass in the right neck.DiagnosesBased on histopathological examination of H&E stained sections, immunohistochemical staining assay and molecular tests, the patient was diagnosed with ATC combined with sclerosing mucoepidermoid carcinoma with eosinophilia.InterventionsThe patient underwent radical surgery for thyroid cancer.OutcomesNo complications, local recurrence or metastases were observed during a 1 year and 3 months follow-up after surgery.LessonsTo the best of our knowledge, this is the first case report on ATC combined with sclerosing mucoepidermoid carcinoma with eosinophilia in the English literature. This condition can be easily misdiagnosed during thyroid fine needle cytology. Clinicians should perform morphological examination, immunohistochemistry and molecular tests on resected specimen to make a definitive diagnosis.

27 keywords...

hide…