• Julia P Engkasan, Aishah Ahmad-Fauzi, Sakinah Sabirin, Chau C Chai, Izwan Z Abdul-Malek, Sara Liguori, Antimo Moretti, and Francesca Gimigliano.
• Department of Rehabilitation Medicine, University of Malaya, Kuala Lumpur, Malaysia - julia@ummc.edu.my.
• Eur J Phys Rehabil Med. 2019 Jun 1; 55 (3): 378-383.

BackgroundThe International Classification of Functioning, Disability and Health (ICF) serves as a framework for defining and categorizing health and functioning. ICF could be used to classify research outcomes in a systematic manner.AimThe aim of this study was to classify the primary outcomes used in Cochrane Systematic Reviews (CSRs) into the ICF domains of functioning; to describe the differences in primary outcomes in reviews related to rehabilitation intervention and non-rehabilitation intervention; and to describe the trend of outcome selections according year of publication.DesignMethodological paper.PopulationAdult stroke population.MethodsWe analyzed the primary outcomes used in the CSRs published by the Cochrane Stroke Review Group up to December 2017. The primary outcomes were extracted and classified into the ICF domains of functioning (body functions, body structures and activity and participation).ResultsOne hundred and seventy-four papers with 216 primary outcomes were included in this analysis. Less than half (102/216, 47.2%) of the outcomes could be classified into the ICF domains of functioning. For the outcomes that could be classified into the ICF domains, the majority (72/102, 70.5%) were in the activity and participation domain, followed by body functions (26/102, 25.5%) and body structures (4/102, 4.0%). Of the outcomes that could not be classified into the ICF domains (N.=114), death (81/114, 71.1%) and recurrent stroke (21/114,18.4%) formed the majority of the outcome. There were 75 CSRs on rehabilitation related interventions; the majority of the outcomes (75/97, 77.3%) used in rehabilitation related CSRs could be classified into the ICF framework with more than half (49/75, 65.3%) in the activity and participation domain.ConclusionsThe majority of the primary outcomes selected by the Cochrane Stroke Review Group in their CSRs could not be classified into the ICF domains of functioning. Death and recurrence of vascular events remains the major outcome of interest. In rehabilitation related interventions, activity and participation domain is the functioning domain most commonly used.Clinical Rehabilitation ImpactThe systematic use of patients-centered ICF-based outcomes in CSRs could help the application of evidence in clinical decision making.

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