• Journal of neurosurgery · Jun 2003

    Randomized Controlled Trial Clinical Trial

    Effect of the local anesthetic agent bupivacaine prior to application of the skull-pin holder for craniotomies.

    • David Mathieu, Mathieu Beaudry, René Martin, Hans McLelland, Bruno Robert, and Brendan Kenny.
    • Department of Neurosurgery, Centre Hospitalier Universitaire de Sherbrooke, Québec, Canada.
    • J. Neurosurg. 2003 Jun 1; 98 (6): 1194-7.

    ObjectThe authors conducted a double-blind prospective randomized study to determine whether infiltration of Mayfield skull-pin sites with 0.5% bupivacaine, compared with placebo, would prevent hemodynamic stimulation, thus allowing for a reduction in the quantity of anesthetic agents required.MethodsThirty patients were randomized into two groups. There was a significant increase in blood pressure (mean systolic blood pressure 10 mm Hg, p = 0.003) in patients in the placebo group compared with that in patients in the bupivacaine group 1 minute after securing the head holder.ConclusionsThe local administration of bupivacaine for anesthetic purposes before skull-pin application may prevent potentially hazardous hemodynamic stimulation.

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