• Medical oncology · May 2018

    Review

    Challenges and prospects of chimeric antigen receptor T cell therapy in solid tumors.

    • Vishal Jindal, Ena Arora, and Sorab Gupta.
    • Department of Internal Medicine, Saint Vincent Hospital, 123 Summer Street, Worcester, MA, 01608, USA. vishaljindal87@gmail.com.
    • Med. Oncol. 2018 May 5; 35 (6): 87.

    AbstractChimeric antigen receptor (CAR) T cell therapy is a novel and innovative immunotherapy. CAR-T cells are genetically engineered T cells, carrying MHC independent specific antigen receptor and co-stimulatory molecule which can activate an immune response to a cancer specific antigen. This therapy showed great results in hematological malignancies but were unable to prove their worth in solid tumors. Likely reasons for their failure are lack of antigens, poor trafficking, and hostile tumor microenvironment. Excessive amount of research is going on to improve the efficacy of CAR T cell therapy in solid tumors. In this article, we will discuss the challenges faced in improving the outcome of CAR T cell therapy in solid tumors and various strategies adopted to curb them.

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