• Danilo Iannetta, Erin Calaine Inglis, Rogerio N Soares, Kaitlin M McLay, Silvia Pogliaghi, Juan M Murias, and CAPES scholarship holder.
• Faculty of Kinesiology, University of Calgary, Calgary, AB, Canada.
• Microvasc. Res. 2019 Mar 1; 122: 117-124.

BackgroundCardiovascular disease (CVD) is associated with impairments in microvascular responsiveness. Therefore, reliably assessing microvascular function is clinically relevant. Thus, this study aimed to examine the reliability of the near-infrared spectroscopy (NIRS)-derived oxygen saturation (StO2) reperfusion slope, a measure of microvascular responsiveness, to four different vascular occlusion tests (VOT) of different durations in young and older participants.MethodsEight healthy young (29 ± 5 yr) and seven older (67 ± 4 yr) men participated in four NIRS combined with VOT (NIRS-VOT; 30 s, 1, 3, and 5 min) in the leg microvasculature on two visits separated by 1-2 weeks. Vascular responsiveness was determined by the StO2 reperfusion slope. The coefficient of variation (CV), repeatability, reliability (ICC), and the limits of agreement (LOA) were calculated for the NIRS-derived reperfusion slopes for each occlusion duration and visit.ResultsCV for the StO2 reperfusion slope following 30 s, 1, 3 and 5 min of occlusion were 33 ± 29%, 19 ± 21%, 14 ± 12%, and 12 ± 10%, respectively. Repeatability values following 30 s, 1, 3 and 5 min occlusions were 20%, 1%, 4% and 21%, respectively. The ICC for the StO2 reperfusion slopes for each occlusion duration were 0.29, 0.42, 0.84, and 0.88 following 30 s, 1, 3 and 5 min of occlusion, respectively. LOA values between visit 1 and 2 for occlusions were not different from zero. There were no age-related differences for all variables of the study.ConclusionNIRS-derived StO2 reperfusion slope, has good reliability across a range of occlusion durations with the strongest reliability during longer occlusion durations.Copyright © 2018 Elsevier Inc. All rights reserved.

42 keywords...

hide…