• Medicine · Oct 2020

    Case Reports

    Iodine-125 radioactive particles antagonize hyperprogressive disease following immunotherapy: A case report.

    • Ning Yang, Pin-Liang Zhang, and Zeng-Jun Liu.
    • Tumor Research and Therapy Center, Shandong Provincial Hospital Affiliated to Shandong First Medical University.
    • Medicine (Baltimore). 2020 Oct 30; 99 (44): e22933.

    RationaleIncreasing evidence has shown that immune checkpoint inhibitors are associated with hyperprogressive disease (HPD). HPD usually resulted in dramatically reduced survival duration, which limited the opportunity to administer other therapies.Patient ConcernsA heavily pretreated lung adenocarcinoma patient experienced rapid progression of rib metastasis soon after immune checkpoint inhibitor -based combination therapy.DiagnosesOn the basis of radiographic and pathological findings, the patient was diagnosed with HPD.InterventionsWe treated the patient with iodine-125 radioactive particle implantation to the metastatic lesions in the chest wall.OutcomesThe metastatic lesions shrank significantly 1 month later.LessonsEarly detection and adequate treatment are essential for prolonged survival when HPD occurs.

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