• Haiyang Yu, Haiyan Wang, Panju Cao, Tao Ma, Yongli Zhao, Feiyang Xie, Chuanjiang Yao, and Xiaogang Zhang.
• Clinical College of Traditional Chinese Medicine, Gansu University of Chinese Medicine.
• Medicine (Baltimore). 2020 Oct 30; 99 (44): e23035e23035.

BackgroundKnee osteoarthritis (KOA) is a degenerative disease, making a unique contribution to chronic pain, edema, and limited mobility of knee joint. This disease is an important factor affecting the quality of life of middle-aged and elderly people. Complementary and alternative medicine (CAM) therapies have been used clinically to treat KOA; however, the selection strategies of different CAM interventions in clinical practice are still uncertain, and the purpose of this study is to evaluate the efficacy and acceptability of different CAM therapies using systematic review and network meta-analysis.MethodsAccording to the strategy, the authors will retrieve a total of 7 electronic databases by October 2020, including PubMed, the Cochrane Library, EMbase, China National Knowledge Infrastructure, China Biological Medicine, Chongqing VIP, and Wan-fang databases After a series of screening, 2 researchers will use Aggregate Data Drug Information System and Stata software to analyze the data extracted from the randomized controlled trials of CAM therapies for the KOA. Finally, the evidence grade of the results will be evaluated.ResultsThis study will provide a reliable evidence for the selection of CAM therapies for KOA.ConclusionThe results of this study will provide references for evaluating the influence of different CAM therapies for KOA, and provide decision-making references for clinical research.Ethics And DisseminationThis study does not require ethical approval. The results will be disseminated through a peer-reviewed publication.Osf Registration NumberDOI 10.17605/OSF.IO/GJMF4.

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