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Ned Tijdschr Geneeskd · Jun 2020
[Hydroxychloroquine and chloroquine for COVID-19: no evidence of effectiveness].
- A Vollaard, E M Gieling, P D van der Linden, B Sinha, and de Boer M G J MGJ LUMC, afd. Infectieziekten, Leiden..
- RIVM, Centrum Infectieziektebestrijding, Bilthoven.
- Ned Tijdschr Geneeskd. 2020 Jun 2; 164.
AbstractOn 3 March 2020, the document 'Drug treatment options for patients with COVID-19 (infections with SARS-CoV-2)' was published on the website of the Dutch Working Party on Antibiotic Policy (StichtingWerkgroepAntibioticabeleid, SWAB). Based on a 7-step analysis of the literature, hydroxychloroquine (HCQ) and chloroquine (CQ) were initially included in the SWAB document as possible drug treatments for hospitalised adult COVID-19 patients. However, recent weeks have seen the publication of the results of various studies into the effectiveness of treatment with HCQ and CQ in patients with COVID-19. On the basis of these results, we conclude that there is insufficient evidence to consider HCQ and CQ as meaningful treatment options in patients with COVID-19. Clinically relevant QTc prolongation occurs in at least 1 in 10 COVID-19 patients treated with HCQ or HQ.
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