• Beatriz Tejera Segura, Susana Holgado, Lourdes Mateo, Jose María Pego-Reigosa, María Carnicero Iglesias, and Alejandro Olivé.
• Servicio de Reumatología, Hospital Universitario Germans Trias i Pujol, Badalona, Barcelona, España. Electronic address: btejerasegura@gmail.com.
• Med Clin (Barc). 2014 Aug 19; 143 (4): 166-9.

Background And ObjectiveLöfgren's syndrome is characterized by hiliar adenopathies, erythema nodosum and arthritis. It is a benign variant of sarcoidosis, common in the Mediterranean area. To describe the clinical characteristics, treatment and outcome of a series of patients diagnosed with Löfgren's syndrome.Patients And MethodsRetrospective design (1984-2013).SettingTwo university hospitals with a reference population of 1,015,000 inhabitants.ResultsEighty patients were diagnosed: 29 men and 51 women (mean age 42.3 years). Forty eight patients (60%) presented with the classical triad: hiliar adenopathies, erythema nodosum and arthritis; 18 (22%) with hiliar adenopathy and arthritis; 13 (16%) hiliar adenopathies and erythema nodosum. All showed abnormalities in the chest study. According to the radiological pattern, patients were classified in stage i-ii. Biopsy was performed in 39 patients and was diagnostic in 28. Treatment was based on non-steroidal anti-inflammatory drugs (54 patients, 67%) and corticosteroids (33 patients, 41%). Fourteen patients (17%) suffered a recurrence of the disease.ConclusionsLöfgren's syndrome is a benign form of sarcoidosis with a well defined clinical pattern. Biopsy is usually not required. Recurrence is scarce. The disease has a good prognosis.Copyright © 2013 Elsevier España, S.L. All rights reserved.

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