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- Dijoia B Darden, Frederick A Moore, Scott C Brakenridge, Eduardo B Navarro, Stephen D Anton, Christiaan Leeuwenburgh, Lyle L Moldawer, Alicia M Mohr, Philip A Efron, and Robert T Mankowski.
- Department of Surgery, University of Florida College of Medicine, 1600 SW Archer Road, Gainesville, FL 32610, USA.
- Crit Care Clin. 2021 Jan 1; 37 (1): 135150135-150.
AbstractOlder patients experience a decline in their physiologic reserves as well as chronic low-grade inflammation named "inflammaging." Both of these contribute significantly to aging-related factors that alter the acute, subacute, and chronic response of these patients to critical illness, such as sepsis. Unfortunately, this altered response to stressors can lead to chronic critical illness followed by dismal outcomes and death. The primary goal of this review is to briefly highlight age-specific changes in physiologic systems majorly affected in critical illness, especially because it pertains to sepsis and trauma, which can lead to chronic critical illness and describe implications in clinical management.Copyright © 2020 Elsevier Inc. All rights reserved.
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