• Critical care clinics · Jan 2021

    Review

    Toxicities Associated with Immunotherapy and Approach to Cardiotoxicity with Novel Cancer Therapies.

    • Cristina Gutierrez, Prabalini Rajendram, and Stephen M Pastores.
    • Department of Critical Care Medicine, University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.
    • Crit Care Clin. 2021 Jan 1; 37 (1): 47-67.

    AbstractIn recent years, major advances in oncology especially the advent of targeted agents and immunotherapies (immune checkpoint inhibitors [ICIs] and chimeric antigen receptor [CAR] T-cell therapy) have led to improved quality of life and survival rates in patients with cancer. This article focuses on the clinical features, and grading and management of toxicities associated with ICIs and CAR T-cell therapy. In addition, because cardiotoxicity is one of the most harmful effects of anticancer therapeutics, we describe the risk factors and mechanisms of cardiovascular injury associated with newer agents, screening technologies for at-risk patients, and preventive and treatment strategies.Copyright © 2020 Elsevier Inc. All rights reserved.

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