• Katy E Trinkley, Michael G Kahn, Larry A Allen, Heather Haugen, Miranda E Kroehl, Chen-Tan Lin, Daniel C Malone, and Daniel D Matlock.
• Department of Clinical Pharmacy, University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, CO, USA.
• Patient Prefer Adher. 2020 Jan 1; 14: 2225-2230.

IntroductionConsideration of patient preferences for guideline-directed medical therapies (GDMT) for heart failure with reduced ejection fraction (HFrEF) may help improve major gaps in prescribing and adherence. This study aimed to identify the range and relative priority of factors influencing patients' decisions to take HFrEF medications.Materials And MethodsThis was a convergent mixed methods study of patients with HFrEF. Focus groups were conducted to identify a list of factors followed by individuals rating and ranking the influence of each factor on their decision to take a medication. Using thematic analysis, we summarized preferences into categories.ResultsTwo focus groups with 13 participants reported 22 factors. Of the factors, "keeping you alive" was most commonly ranked in the top three (seven participants), followed by "communication and understanding" (six participants). Factors were summarized into six categories (listed in order of patient-reported influence): 1) demonstrated improvements in quality of life and longevity, 2) decreased risk of hospitalization, 3) opportunity for shared decision-making and trust in provider, 4) absence of adverse events, 5) affordability, and 6) convenience of taking and absence of interference with daily life.ConclusionPatients prioritize treatment benefits and being informed more than risks, cost and inconvenience of taking HFrEF medications.© 2020 Trinkley et al.

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