• Emerg. Med. Clin. North Am. · Feb 2021

    Review

    Central Nervous System Infections in the Immunocompromised Adult Presenting to the Emergency Department.

    • Robert J Stephens and Stephen Y Liang.
    • Department of Emergency Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA. Electronic address: stephensr@wustl.edu.
    • Emerg. Med. Clin. North Am. 2021 Feb 1; 39 (1): 101-121.

    AbstractOver the past 2 decades, the population of immunocompromised patients has increased dramatically in the United States. These patients are at elevated risk for both community-acquired and opportunistic central nervous system infections. We review the most common and serious central nervous system pathogens affecting these patients and outline a diagnostic and therapeutic approach to their management in the emergency department. We recommend a broad diagnostic evaluation, including neuroimaging and cerebrospinal fluid studies where appropriate, empiric antimicrobial therapy, and early involvement of subspecialists to provide comprehensive care for these complex patients.Copyright © 2020 Elsevier Inc. All rights reserved.

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