• S. Afr. Med. J. · Apr 2016

    Emergence of plasmid-mediated colistin resistance (MCR-1) among Escherichia coli isolated from South African patients.

    • Jennifer Coetzee, Craig Corcoran, Elizabeth Prentice, Mischka Moodley, Marc Mendelson, Laurent Poirel, Patrice Nordmann, and Adrian John Brink.
    • Departments of Clinical Microbiology and Molecular Sciences, Ampath Reference Laboratory, Centurion, Pretoria, South Africa. coetzeej@ampath.co.za.
    • S. Afr. Med. J. 2016 Apr 19; 106 (5): 35-6.

    AbstractThe polymyxin antibiotic colistin is an antibiotic of last resort for the treatment of extensively drug-resistant Gram-negative bacteria, including carbapenemase-producing Enterobacteriaceae. The State of the World's Antibiotics report in 2015 highlighted South Africa (SA)'s increasing incidence of these 'superbugs' (3.2% of Klebsiella pneumoniae reported from SA were carbapenemase producers), and in doing so, underscored SA's increasing reliance on colistin as a last line of defence. Colistin resistance effectively renders such increasingly common infections untreatable.

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