• Arch Intern Med · Oct 1985

    Case Reports

    Fatal acute respiratory failure after vinblastine-mitomycin therapy in lung carcinoma.

    • S X Rao, G Ramaswamy, M Levin, and J W McCravey.
    • Arch Intern Med. 1985 Oct 1; 145 (10): 1905-7.

    AbstractThe occurrence of pulmonary toxic reaction due to vinblastine sulfate alone or in combination with drugs other than mitomycin is not known. Acute respiratory distress is a rare phenomenon in patients receiving both chemotherapeutic agents. Two cases of fatal acute respiratory failure due to pulmonary edema occurred in patients receiving vinblastine-mitomycin for non-small-cell carcinoma of the lung. In view of the unpredictability of the reaction, observation of patients receiving this combination therapy is recommended.

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