• Am. J. Med. Sci. · Sep 1992

    Review

    Epidermodysplasia verruciformis as a model of human papillomavirus-induced genetic cancers: the role of local immunosurveillance.

    • S Majewski and S Jablonska.
    • Department of Dermatology, Warsaw School of Medicine, Poland.
    • Am. J. Med. Sci. 1992 Sep 1; 304 (3): 174-9.

    AbstractEpidermodysplasia verruciformis (EV) presents a genetically determined, unusual susceptibility to infection with EV-specific human papillomaviruses (HPVs) related to abrogation of immunosurveillance exclusively against these viruses. The cutaneous viral carcinogenesis depends upon potentially oncogenic HPVs, the cocarcinogenic effect of ultraviolet irradiation, and genetic host factors, presumably a defect of anti-oncogenes or alleles of major histocompatibility complex and tumor necrosis factor locus involved in antigen presentation.

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