• Terapevt Arkh · Jul 2020

    [Monoclonal gammapathy of renal significance (MGRS) at the current state: terminology, diagnosis and treatment].

    • L V Lysenko Kozlovskaya, V V Rameev, and T V Androsova.
    • Sechenov First Moscow State Medical University (Sechenov University).
    • Terapevt Arkh. 2020 Jul 9; 92 (6): 15-22.

    AbstractIn this article we discussed the current state of monoclonal gammapathy of renal significance (Monoclonal Gammopathy of Renal Significance MGRS) and revealed problems of B-cell clone secreting nephrotoxic monoclonal immunoglobulin identification. We followed 276 patients with monoclonal gammapathy including patients with non-amyloid nephropathy. The majority of patients had systemic AL-amyloidosis. We established better survival of the treated patients with systemic AL-amyloidosis in comparison with retrospective untreated cohort. We considered current treatment of patients with non-amyloid nephropathy and focused on the crucial role of multidisciplinary approach in management of these patients.

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