Dysphagia due to isoniazid therapy for tuberculosis in a patient

Auris, nasus, larynx · Jun 2013

Case Reports

Dysphagia due to isoniazid therapy for tuberculosis in a patient with Lewy body dementia.

Dementia with Lewy bodies (DLB) potentially causes dysphagia; however, the features and underlying mechanism causing dysphagia have still not been clarified. We are the first to report a case of dysphagia resulting from isoniazid therapy for tuberculosis in a DLB patient. A 74-year-old woman with DLB developed dysphagia during treatment for tuberculous pleurisy. ⋯ The increased administration of levodopa successfully ameliorated dysphagia. Therefore, dysphagia was ascribed to diminished levodopa efficacy due to interaction with isoniazid. Thus, DLB patients receiving anti-tuberculous therapy should be closely examined for potential changes in swallowing and Parkinsonism.

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- Masafumi Ohki and Niro Tayama.
- Department of Otolaryngology, Saitama Medical Center, Saitama Medical University, 1981 Kamoda, Kawagoe-shi, Saitama, Japan. m-ohki@umin.ac.jp
- Auris Nasus Larynx. 2013 Jun 1; 40 (3): 327-9.
AbstractDementia with Lewy bodies (DLB) potentially causes dysphagia; however, the features and underlying mechanism causing dysphagia have still not been clarified. We are the first to report a case of dysphagia resulting from isoniazid therapy for tuberculosis in a DLB patient. A 74-year-old woman with DLB developed dysphagia during treatment for tuberculous pleurisy. Oral videoendoscopic and videofluorographic swallowing examinations showed oropharyngeal dysphagia. The increased administration of levodopa successfully ameliorated dysphagia. Therefore, dysphagia was ascribed to diminished levodopa efficacy due to interaction with isoniazid. Thus, DLB patients receiving anti-tuberculous therapy should be closely examined for potential changes in swallowing and Parkinsonism.Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

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Dysphagia due to isoniazid therapy for tuberculosis in a patient with Lewy body dementia.

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