• Clin. Infect. Dis. · Jul 2021

    Warp Speed for COVID-19 Vaccines: Why are Children Stuck in Neutral?

    • Evan J Anderson, James D Campbell, C Buddy Creech, Robert Frenck, Satoshi Kamidani, Flor M Munoz, Sharon Nachman, and Paul Spearman.
    • Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.
    • Clin. Infect. Dis. 2021 Jul 15; 73 (2): 336-340.

    AbstractWhile adult clinical trials of coronavirus disease 2019 (COVID-19) vaccines have moved quickly into phase 3 clinical trials, clinical trials have not started in children in the United States. The direct COVID-19 impact upon children is greater than that observed for a number of other pathogens for which we now have effective pediatric vaccines. Additionally, the role of children in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission has clearly been underappreciated. Carefully conducted phase 2 clinical trials can adequately address potential COVID-19 vaccine safety concerns. Delaying phase 2 vaccine clinical trials in children will delay our recovery from COVID-19 and unnecessarily prolong its impact upon children's education, health, and emotional well-being, and equitable access to opportunities for development and social success. Given the potential direct and indirect benefits of pediatric vaccination, implementation of phase 2 clinical trials for COVID-19 vaccines should begin now.© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

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