• Asian Pac. J. Cancer Prev. · Jan 2016

    Impact of Peri-Operative Anemia and Blood Transfusions in Patients with Gastric Cancer Receiving Gastrectomy.

    • Chih-Chun Chang, Jen-Tang Sun, Jing-Yuan Chen, Yi-Ting Chen, Pei-Yu Li, Tai-Chen Lee, Ming-Jang Su, Jiann-Ming Wu, Tzung-Hai Yen, and Fang-Yeh Chu.
    • Department of Clinical Pathology, Far Eastern Memorial Hospital, New Taipei, Taiwan E-mail : jacpha@mail.femh.org.tw.
    • Asian Pac. J. Cancer Prev. 2016 Jan 1; 17 (3): 1427-31.

    BackgroundPotential disadvantages of blood transfusion during curative gastrectomy for gastric cancer have been reported, and the role of peri-operative transfusions remains to be ascertained. Thus, the aim of our study was to survey its impact in patients with gastric cancer undergoinging gastrectomy.Materials And MethodsClinical data of patients receiving curative gastrectomy at Far Eastern Memorial Hospital were obtained. Findings for pre-operative anemia states, pre-, peri- and post-operative transfusion of red blood cell (RBC) products as well as post-operative complication events were collected for univariate analysis.ResultsA total of 116 patients with gastric cancer received gastrectomy at Far Eastern Memorial Hospital from 2011 to 2014. Both pre-operative and intra- and post-operative transfusion of RBC products were markedly associated with post-operative infectious events (OR: 3.70, 95% CI: 1.43-9.58, P=0.002; OR: 8.20, 95% CI: 3.11-22.62, P<0.001, respectively). In addition, peri- and post-operative RBC transfusion was significantly associated with prolonged hospital stay from admission to discharge (OR: 8.66, 95% CI: 1.73-83.00, P=0.002) and post-operative acute renal failure (OR: 19.69, 95% CI: 2.66-854.56, P<0.001). Also, the overall survival was seemingly decreased by peri-operative RBC transfusion in our gastric cancer cases (P=0.078).ConclusionsOur survey indicated that peri-operative RBC transfusion could increase the risk of infectious events and acute renal failure post curative gastrectomy as well as worsen the overall survival in gastric cancer cases. Hence, unnecessary blood transfusion before, during and after curative gastrectomy should be avoided in patients with gastric cancer.

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