• Cheng Cheng, Yashuang Huang, Li Xie, Xinghui Zhu, Dongmei Chen, and Cisong Cheng.
• School of Basic Medicine, Chengdu University of Traditional Chinese Medicine.
• Medicine (Baltimore). 2021 Jan 8; 100 (1): e24120e24120.

BackgroundEvaluating the effectiveness and safety of external treatment of traditional Chinese medicine therapy for COVID-19 with diarrhea is the primary purpose of this systematic evaluation program.MethodsWe will search the randomized controlled trials from inception to November 2020. The following database is our focus area: Cochrane Central Register of Controlled Trials, Embase, PubMed, Web of Science, China National Knowledge Infrastructure (CNKI), Chinese Biomedical Database (CBM), VIP database for Chinese technical Periodicals, and Wanfang Database. We will choose articles published both in Chinese and English. Two reviewers will conduct the study selection, data extraction, and assessment independently. The assessment of risk of bias and data synthesis will be carried out using Review Manager Software V.5.3.ResultsThe results will provide high-quality synthesis of current evidence for researchers in this subject area.ConclusionThis studys decision will provide evidence of whether external treatment of traditional Chinese medicine is an effective and safe intervention for coronavirus disease 2019 with diarrhea.Registration NumberINPLASY2020110095 (DOI number: 10.37766/inplasy2020.11.0095).Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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