• Saima Ejaz, Anwar Ali, Sumaira Riffat, Atif Mahmood, and Kamran Azim.
• Saima Ejaz Ph.D. Scholar, Department of Physiology, University of Karachi, Pakistan.
• Pak J Med Sci. 2021 Jan 1; 37 (1): 109-113.

ObjectiveThe study was performed to investigate the association of hypertension in pregnancy with prostasin gene polymorphism in Pakistani females.MethodsThis case-control study was performed at University of Karachi, Pakistan from April 2018 to May 2019. A total of 160 females, including 90 hypertensives and 70 healthy pregnant females, were recruited by purposive sampling after obtaining informed written consent. Genotyping was performed by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP).ResultsThe frequencies of the TC and CC genotypes were higher in hypertensive pregnant females compared to healthy controls. A significant difference was evident for CC (P=0.012) genotype; however, no significant difference was observed for TC (P=0.49) and TT genotypes (P=0.06) between control and hypertensive groups. The adjusted odds ratio for CC genotype was 6.2 (P=0.025) and 1.48 (P=0.44) for TC genotype compared to the TT genotype. There was a significantly higher prevalence of the C allele of the prostasin gene at rs12597511 in the hypertensive group, suggesting that this allele is a risk factor for hypertension and cardiovascular diseases.ConclusionC allele at rs12597511 of prostasin gene demonstrate as a risk factor for having hypertension in pregnancy.Copyright: © Pakistan Journal of Medical Sciences.

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