• Nida Riaz, Muhammad Ajmal, and Muhammad Sheharyar Khan.
• Dr. Nida Riaz, FCPS. Department of Otorhinolaryngology and Head and Neck Surgery, Holy Family Hospital, Rawalpindi, Pakistan.
• Pak J Med Sci. 2021 Jan 1; 37 (1): 212-216.

ObjectiveTo determine the efficacy of usage of topical autologous platelet rich fibrin (PRF) in improving outcomes of myringoplasty regarding graft uptake and hearing improvement.MethodsThis study was conducted in the ENT department of Holy Family Hospital, Rawalpindi, over a period of six months from August 2019 to January 2020. It was designed as a prospective single blinded randomized controlled trial. The study involved a total of 50 participants in whom myringoplasty was done through post auricular approach using underlay technique. In 25 patients topical drops of PRF were used. Outcomes were compared after three months with the control group (n=25), who underwent myringoplasty without PRF.ResultsAfter three months follow-up, graft uptake was reported 78% and 52% in cases and controls, respectively (P=0.070). Mean hearing improvement was 18 dB and 6 dB in cases and controls, respectively (P=0.014). Postoperative infection occurred in 8% of the cases, and in 32% controls (P=0.037).ConclusionTopical use of Platelet-Rich Fibrin during myringoplasty results in improved graft uptake. Hence, resulting in much improved hearing, significant reduction in infection rates and decrease in perforation sizes.Copyright: © Pakistan Journal of Medical Sciences.

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