• Medicina · Jan 2021

    Review

    Therapeutic Strategies for the Treatment of Chronic Hyperuricemia: An Evidence-Based Update.

    • Cicero Arrigo F G AFG 0000-0002-4367-3884 Hypertension Research Unit, Department of Medical and Surgical Sciences, University of Bologna, 40126 Bologn, Federica Fogacci, Masanari Kuwabara, and Claudio Borghi.
    • Hypertension Research Unit, Department of Medical and Surgical Sciences, University of Bologna, 40126 Bologna, Italy.
    • Medicina (Kaunas). 2021 Jan 10; 57 (1).

    AbstractThis article aims to critically review the evidence on the available therapeutic strategies for the treatment of hyperuricemia. For this reason, several papers were reviewed. Xanthine oxidase inhibitors are the safest and most effective uric acid lowering drugs for the management of chronic hyperuricemia, while the efficacy of uricosuric agents is strongly modulated by pharmacogenetics. Emergent drugs (lesinurad, peglotidase) were found to be more effective for the acute management of refractory hyperuricemia, but their use is supported by a relatively small number of clinical trials so that further well-designed clinical research is needed to deepen their efficacy and safety profile.

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