• Yusuke Amano, Kentaro Tsuji, Atshushi Kihara, Daisuke Matsubara, Noriyoshi Fukushima, Hiroshi Nishino, and Toshiro Niki.
• Department of Pathology.
• Medicine (Baltimore). 2021 Jan 15; 100 (2): e24011e24011.

RationaleSalivary duct carcinoma (SDC) is a rare and highly aggressive cancer with a poor prognosis. SDC demonstrates a potential for invasive growth with early regional and distant metastasis to organs, such as bone, lung, liver, and brain. Because, adrenal gland metastasis from SDC is rare, its treatment options are not well established. Herein, we report a case of SDC metastasis from the parotid gland to the adrenal gland, which was successfully treated by surgery.Patient ConcernsThe patient had an abnormal but painless lump on the right parotid gland. The size of the mass had increased over a period of 3 years. The patient underwent complete removal of the right parotid gland and radical neck dissection followed by adjuvant radiotherapy and chemotherapy. Two years later, a mass was identified in the left adrenal gland by computed tomography. As no local recurrence or metastasis to other organs was observed, the patient underwent adrenalectomy.DiagnosesMetastasis of SDC in the adrenal gland was confirmed by histopathological examination of the adrenalectomized specimen.InterventionsAfter adrenalectomy, the patient was followed-up without adjuvant therapy.OutcomesThe patient was well and alive during the 13-month postoperative follow-up period without any complications.LessonsSurgical resection of solitary metastatic lesion may show a survival benefit with metastatic SDC.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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