• Seminars in nephrology · Jan 2018

    Review

    Phenotyping of Acute Kidney Injury: Beyond Serum Creatinine.

    • Dennis G Moledina and Chirag R Parikh.
    • Program of Applied Translational Research, Section of Nephrology, Department of Internal Medicine, Yale School of Medicine, New Haven, CT.
    • Semin. Nephrol. 2018 Jan 1; 38 (1): 3-11.

    AbstractAcute kidney injury (AKI) is a common complication in hospitalized patients and is associated with adverse short- and long-term outcomes. AKI is diagnosed by serum creatinine (SCr)-based consensus definitions that capture an abrupt decrease in glomerular filtration rate associated with AKI. However, SCr-based AKI definitions lack sensitivity and specificity for diagnosing structural kidney injury. Moreover, AKI is a heterogeneous condition consisting of distinct phenotypes based on its etiology, prognosis, and molecular pathways, and that may potentially require different therapies. SCr-based AKI definitions provide no information on these AKI phenotypes. This review highlights traditional and novel tools that overcome the limitations of SCr-based AKI definitions to improve AKI phenotyping.Copyright © 2017 Elsevier Inc. All rights reserved.

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